Sanghee Lee'
Lab

47

Hahm, J; Park, J ; Lee, H ; Hwang, H.M.; Lee, S; Park, J-Y.; V, ARUN; Lee, S*; Kim , E; Park, J

Investigation of proteome-tetrazine reactivity for a highly selective tetrazine ligation in live cells. Submitted

46

Wi, J.H.‡; Lee, H.‡; Park, J.M.; Heo, Y.; Jo, S.; Lee, J.; Jung, C.; Kim, N-J.; Song, G. Y.; Kim, P.*; Kim, H.*; Lee, S.* 

Development of a TBK1 and ALK dual inhibitor for alleviating depressive behavior via anti-inflammatory effects. Submitted

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45

Park, J. Y.‡; Kang, M.‡; Lim, S.‡; Cho, H.; Yang, S.; Baek, S.Y.;Tan, L.; Song, C.; Lee, M.; Lee, S.*; Kim, Y.*

Assembly of 2’,3’-Cyclic Guanosine Monophosphate-Adenosine Monophosphate and Their Spontaneous Intracellular Disassembly for Enhanced Antitumor Immunity via Natural STING Pathway Activation. Chem. Eng. J. 2024, 500, 157037.

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44

Lee, H.‡; Park, J-Y.‡; Yoon, J; Park, W.; Park, G.; Koh, M.; Sohn, C. H.; Lee, S.*; Kim, E.*

Bioorthogonal imaging probe for STING protein in live cell and fixed tissue. Sens. & Actuators B Chem. 2024, 412, 135773.

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43

Yang, H.; Kang, M.; Jang, S.; Baek, S. Y.; Kim, J.; Kim, K. U.;Jung, C.; Kim, N-J.; Cho, S-Y.; Shin, W-H.;Lee, J.; Ko, J.; Lee, A.; Keum, G.; Lee, S.*; Kang, T.*

Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability. Bioorganic. Med. Chem. 2024, 100, 117588.

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42

Jeong, J. H.; Lee, H.; Kim, D.; Park, E.; Woo, J.; Cho, Y.; Keum, G.; Lee, A.; Kang, T.; Kim, J.; Choo, H.; Lee, S.; Jeon, B.*

Discovery of Dual Antagonists in G protein and b-Arrestin Signaling Pathways of 5-HT7R. 

ACS Chem. Neurosci. 2024, 15, 1026.

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41

Kang, D.Y.‡; Jang, Y.‡; Lee, H.‡; Lee, J.; Kang, M.; Lee, S.*; Lee, S.*

Optogenetic STING Clustering System through Nanobody-Fused Photoreceptor for Innate Immune Regulation.

Sens. & Actuators B Chem. 2024, 399, 134822.

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40

Yoo, Y.‡; Baek, S.Y.‡; Lee, H.; Lee, J.; Lee, H.; Choi, H-S.; Lee, J. T.; Nam, M-H.; Lee, S.*; Jeon, B.*

Neuroprotective effects of diosgenin derivatives with anti-inflammatory effects for antidepressant potential. submitted

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39

Lim, S.; Jung, H. R.; Lee, H.; Chu, Y.; Kim, H.; Kim, E.; Lee, S.*

Microtubule-destabilizing agents enhance STING-mediated innate immune response via biased mechanism in human monocyte cells.

Biomed. Pharmacother. 2023, 169, 115883.

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38

Jeon. M. J.‡; Lee. H.‡; Jo. S.; Kang. M.; Jeong. J. H.; Lee. J-Y.; Song. G. Y.; Choo. H.; Lee. S.*; Kim. H.*

Discovery of Novel Amidobenzimidazole Derivatives as Orally Available Small Molecule Modulators for Stimulator of Interferon Genes for Immunotherapy. 

Eur. J. Med. Chem. 2023, 261, 115834.

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37 

Cho. Y.‡; Kang. M.‡; Ji. S. H.; Jeong. H. J.; Jung. H. E.; Oh. D.H.; Park. S. Y.; Park. Y-Y.; Choi. J.; Kim. S.; Kim. N-J.; Lee. D-H.; Park. C.S.*; Han. S-J.*; Lee.S.*; Choi. J.*

Discovery of Orally Bioavailable Phthalazinone Analogs as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy.

J. Med. Chem. 2023, 66, 15141.

• selected as a supplemental cover

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36

Lee. H.‡; Jeong. J. H.‡; Chong. Y.*; Choo. H.*; Lee.S.*​

Identification of (-)-Epigallocateshin Gallate Derivatives promoting innate immune activation via cGAMP-STING pathway. 

Bioorganic Med. Chem. Lett. 2023, 90, 129325.

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35

Baek.S.Y.‡; Kim. Y.‡; Park. H.; Jung. H.R.; Jeon. M. J.; Moon. H. E.; Son. J. H.; Kim. H.; Park. H. R.; Paek. S. H.*; Lee. S.*

Stimulator of interferon genes (STING) activation triggers immune surveillance and inhibits tumor growth in glioblastoma. Submitted

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34

Lim.S; Lee, S.*

Chemical Modulators for Targeting Autism Spectrum Disorders: from Bench to Clinic.  

Molecules 2022, 27, 5088.

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33

Lee.J; Choi,S-K.; Aslam, A. S.; Lim, W.; Lee, J.; Ko, J.; Jung, Y.M.; Yoo, H. S.; Park, J. H.; Lee, S.; Park, J.*; Kim, E.*

N-4-Phenyl quinazoline-4,6-diamine as a tunable fluorescent scaffold for the fluorescent probes. 

Dyes Pigm. 2022, 210, 110987.

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32

Jeong.H.J.‡; Lee.H.‡; Kim.S.J.‡; Jeong.J.H.; Ji.S.H.; Kim.H.B.; Kang.M.; Park. C.S.; Choo. H.; Yoon. H. J.; Kim. N-J.; Lee. D-H.; Lee. S.*; Han. S-J.*

Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors.

J. Enzyme Inhib. Med. Chem. 2022, 37, 2434.

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31

Jeon.M.J.‡; Lee.H.‡; Lee. J.; Baek,S.Y.; Lee. D.; Jo.S.; Lee. J-Y.; Kang.M.; Jung. H. R.; Han. S. B.; Kim.N-J.; Lee.S.*; Kim.H.*

Development of Potent Immune-modulators Targeting Stimulator of Interferon Genes Receptor.

J. Med. Chem. 2022, 65, 5407.

• selected as a supplemental cover

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30

Baek, S.Y.; Kim,T.; Lee,H.; Lee,J.; Choi,H-S.; Koh, M.; Kim, E.; Jung, M.E.; Iliopoulos, D.; Kim,J.*; Lee,S.*

Development of a novel histone deacetylase inhibitor unveils the role of HDAC11 in alleviating depression by inhibition of microglial activation. Biomed. Pharmacother. 2023, 166,  115312.

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29

Jung,H.‡; Jo,S.‡; Jeon,M.J.; Lee,H.; Chu,Y.; Lee,J.; Kim,E.; Song,G.Y.; Jung,C.; Kim,H*.; Lee,S.*

Development of small-molecule STING activators for cancer immunotherapy. 

Biomedicines 2022, 10, 33.

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28

Lee, S.‡; Kim, J.‡; Koh, M.*

Recent advances in fluorescence imaging by genetically encoded non-canonical amino acids

Journal of Molecular Biology 2022, 434, 167248.

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27

Chu, Y.; Park, J.; Kim, E.*; Lee, S.*​​

Fluorescent materials for monitoring mitochondrial biology

Materials 2021, 14, 4180.

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26

Choi,S-K.; Lee, Y.; Yoon, S.E.; Choi.S.; Kim. J.; Kim. J.H.; Lee, S.*; Kim, W.*; Kim, E.*

A Tetrazine fused aggregation induced emission luminogen for bioorthogonal fluorogenic molecular bioimaging with spatiotemporal control

Sens. & Actuators B Chem. 2021, 340, 129966.

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25

Kim, E and Lee, S*

Small-molecule interferon inducers for cancer immunotherapy targeting non-T cell-inflamed tumors

J. Cancer Immunol. 2021, 3, 13-17.

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24

Kim, H; Choi, S-K. ; Ahn, J.; Yu, H.; Min, K; Hong, C.; Shin, I-S.; Lee, S.; Lee, H.; Im, H.; Ko, J. ; Kim, E.*

Kaleidoscopic fluorescent arrays for machine-learning-based point-of-care chemical sensing

Sens. & Actuators B Chem. 2021, 329, 129248

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23

Choi, S.K.; Rho,J; Yoon,S.E.; Seok,J-H.; Kim,H; Min,J.; Yoon,W.; Lee,S.; Yun,H.; Kwon,O-P.; Kim,J.H.; Kim,W.; Kim,E.*

Full Color Tunable Aggregation-Induced Emission Luminogen for Bioimaging Based on an Indolizine Molecular Framework

Bioconjugate. Chem. 2020, 31, 2522–2532.

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22

Chu, Y.+; Reddy, R.S.+; Gajulapalli, V. P. R.+; Babu. K.S.*; Kim, E.*; Lee, S*

Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers

Bioorganic Med. Chem. Lett. 2020, 30, 127613.

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21

Lee, S. Y.; Lee, R.; Kim, E.; Lee, S.*; Park, Y. I.*

Near-infrared light-triggered photodynamic therapy and immune response using upconversion nanoparticles with dual photosensitizers.

Front. Bioeng. Biotechnol. 2020, 8, 275

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20

Chu, Y.; Shin, M. C.; Sung, J.; Park, J.; Kim, E.*; Lee, S.*

Development of theragnostic tool using NIR fluorescence probe targeting mitochondria in brain tumor.

Bioconjugate. Chem. 2019, 30, 1642-1648.

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19

Sawant, V. S.; Park,H.; Baek, S. Y.; Seong,J.; Choi, J. W.; Park,K.D.; Choi,K.I.; Lee,S.*; Choo, H.*

Benzoxazoles as selective monoamine oxidase (MAO) B inhibitors.

Bull. Korean Chem. Soc. 2019, 40, 457–460.

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18 

Sung, J.; Rho, J.; Jeon, G.; Chu, Y.; Min, J.; Lee, S.; Kim, J. H.; Kim, W.; Kim, E.

A new-infrared probe targeting mitochondria via regulation of molecular hydrophobicity.

Bioconjugate. Chem. 2019, 30, 210–217.

• selected as an ACS Editors' Choice

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17

Lee, S.+; Cho, W.+; Hong, S.; Yi, S.; Kim, H.; Baek, S. Y.; Park, H.; Jung, J.; Shin, Y.K.; Park, S.B.

Phenotype-based discovery of a HeLa-specific Cytotoxic molecule that downregulates HPV-mediated signaling pathways via oxidative damage.

Org. Biomol. Chem. 2019, 17, 7388-7397.

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16

Jo, A.; Sung, J.; Lee, S.; Nam, H.; Lee,  H.W.; Park, J.; Kim, H.M.; Kim, E.; Park, S.B

Near-IR fluorescent tracer for glucose uptake monitoring in live cell .

Bioconjugate. Chem. 2018, 29, 3394–3401.  

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15

Cho, W.; Koo, J. Y.; Park, Y.; Oh, K.; Lee, S.; Song, J-S.; Bae, M.A.; Lim, D.; Lee, D.; Park, S.B.

Treatment of Sepsis Pathogenesis with High Mobility Group Box Protein 1-Regulating Anti-inflammatory Agents.

J. Med. Chem. 2017, 60, 170–179.

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14

Park, J.; Koh, M.; Koo, J. Y.; Lee, S.; Park, S.B.

Investigation of Specific Binding Proteins to Photoaffinity Linkers for Efficient Deconvolution of Target Protein.

ACS Chem. Biol. 2016, 11, 44–52.

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13

Kim, E.; Lee, Y.; Lee, S.; Park, S.B.

Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor.

ACC. Chem. Res. 2015, 48, 538–547.

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12

Lee, S.; Nam, Y.; Koo, J.Y.; Lim, D.; Park, J.; Ock, J.; Kim, J.; Suk, K.; Park, S.B.

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation.

Nat. Chem. Biol. 2014, 10, 1055–1060.

• highlighted as “News and View” Neuroinflammation: Modulating mighty microglia Nat. Chem. Biol. 2014, 10, 988–989.

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11

Lee, S.; Kim, E; Park, S.B.

Discovery of autophagy modulators through the construction of high-content screening platform by monitoring lipid droplets.

Chem. Sci. 2013, 4, 3282–3287.

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10

Lee, S.; Jo, A.; Park, S.B.

Discovery of highly selective FLT3 kinase inhibitor from phenotypic cell viability profiling.

Med. Chem. Comm. 2013, 4, 228–232.

• selected as a Front cover

• highlighted as “NEW TALENT” in Medicinal Chemistry

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9

Lee, Y.; Na, S.C.; Lee, S.; Jeon, N.L.; Park, S.B.

Optimization of Seoul-Fluor-based lipid droplet bioprobe and its application in microalgae for bio-fuel study.

Mol. BioSyst. 2013, 9, 952–956.

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8

Park, J.W.; Na, S.C.; Lee, Y.; Lee, S.; Park, S.B.; Jeon, N.L.

Measurement of accumulation kinetics for lipid droplets in microalgae using SF44.

Energies, 2013, 6, 5703–5716.

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7

Ju, K-Y.; Lee, J.W.; Im, G.H.; Lee, S.; Pyo, J.; Park, S.B.; Lee, J.H.; Lee, J-K.

Bio-inspired, melanin-like nanoparticles as a highly efficient contrast agent for T1-weighted magnetic resonance imaging.

Biomacromolecules 2013, 14, 3491–3497.

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6

Kim, E.+; Lee, S.+; Park, S.B.

Seoul-Fluor-based bioprobe for lipid droplet and its application in image-based high-throughput screening.

Chem. Commun. 2012, 48, 2331–2333.

(+These authors equally contributed to this work)

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5

Kim, E.; Lee, S.; Park, S.B.

9-Aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one (Seoul-Fluor) as a smart platform for colorful ratiometric fluorescent pH sensors.

Chem. Commun. 2011, 47, 7734-7736.

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4

Lim, S-Y.; Lee, S.; Park, S. B.; Kim, H-J.

Highly selective fluorescence turn-on probe for glutathione.

Tet. Lett. 2011, 52, 3902-3904.

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3

Ju, K-Y.; Lee, Y.; Lee, S.; Park, S. B.; Lee, J-K.

Bioinspired polymerization of dopamine to generate melanin nanoparticles having excellent free radical-scavenging property.

Biomacromolecules 2011, 12, 625-632.

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2

Zhu, M.; Kim, M. H.; Lee, S.; Kim, S. H.; Park, S. B.

Discovery of novel benzopyranyl tetracycles that act as inhibitors of RANKL-induced osteoclastogenesis.

J. Med. Chem. 2010, 53, 8760-8764

• selected as "This week in therapeutics" by SciBX, 2010, 3(48).

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1

Lee, S.; Park, S. B.

An efficient one-step synthesis of hetero-biaryl pyrazolo[3,4-b]pyridines via indole-ring opening.

Org. Lett. 2009, 11, 5214-5217.